Research Projects
This page presents the research projects involving members of the department in a structured archive format, including project team, project title, project number and year/status information.
| Team | Project Title | Project No. | Year |
|---|---|---|---|
| Çoğulu, Özgür; Gündüz, Cumhur; Çankaya, Tufan; Özkınay, Ferda; Özkınay, Cihangir | Screening of subtelomeric chromosomal regions in idiopathic mental retardation | TÜBİTAK SBAG Project 102S024 | 2004 |
| Tosun, Metiner; Akçalı, K. Can; Kosova, Buket; Eraç, Yasemin | The role of differential expression of the TRPC gene family in rat vascular smooth muscle during aging | TÜBİTAK SBAG Project 103S176 | 2007 |
| Tosun, Metiner; Kosova, Buket; Eraç, Yasemin; Selli, Çiğdem | Control of capacitative calcium entry in the development of vasospasm through pharmacological and molecular approaches | TÜBİTAK SBAG Project 104S568 | 2007 |
| Kosova, Buket; Tezcanlı, Burçin; Eroğlu, Zuhal; Gündüz, Cumhur; Topçuoğlu, Nejat; Selvi, Nur; Biray, Çığır; Özel, Rukiye; Saydam, Güray; Şahin, Fahri | Permanent suppression of STAT3, STAT5A and STAT5B expression in leukemia cell lines using antisense oligonucleotides and siRNA, and induction of apoptosis | TÜBİTAK SBAG Project 105S459 | 2008 |
| Kaymaz B. | Investigation of the sequential use of cytosine arabinoside and L-asparaginase in the acute lymphoblastic leukemia model cell line CCRF-CEM and their effects on each other's cytotoxic properties; Turkish Hematology Association Research Project | Project Supported by Other Private Institutions THD2006 | 2008 |
| Özkınay, Ferda; Kurugöl, Zafer; Çoker, Mahmut; Çoğulu, Özgür; Gündüz, Cumhur; Pehlivan, Sacide; Akın, Haluk; Koturoğlu, Güldane; Onay, Hüseyin; Ekmekçi, Aslıhan; Aykut, Ayça; Biray, Çığır | The association between vitamin D receptor polymorphism expression in maternal hair follicle cells and vitamin D levels in breast milk and infant serum among breastfeeding mothers and their infants | TÜBİTAK SBAG Project 106S048 | 2008 |
| Bütüner B.D., Korkmaz K.S., Angın M. | The significance of the tumor-suppressive capacity of the NKX3.1 transcription factor and investigation of its target genes in prostate cancer | TÜBİTAK SBAG Project 106S200 | 2009 |
| Gündüz, Cumhur; Oktar, Nezih; Çoğulu, Özgür; Akalın, Taner; Dalbastı, Tayfun | Determination of epigenetic alterations in tumor suppressor genes in diffuse and high-grade glial tumors using real-time PCR-based quantitative analysis of methylated alleles | TÜBİTAK SBAG Project 107S364 | 2010 |
| Tosun, Metiner; Erdal, Ş. Esra; Kosova, Buket; Eraç, Yasemin | Investigation of the functional expression pattern of the TRPC gene family in carcinogenesis through post-transcriptional gene silencing | TÜBİTAK SBAG Project 108S072 | 2011 |
| Lambrecht, Fatma Yurt; Durkan, Kübra; Gündüz, Cumhur | Preparation and in vitro evaluation of technetium-99m-labeled bombesin-like peptide conjugation as a tumor imaging agent: HYNIC-litorin | TÜBİTAK SBAG Project 108S200 | 2011 |
| Aktuğ, Hüseyin; Kosova, Buket; Uysal, Ayşegül; Yavaşoğlu, Altuğ; Çetintaş, Vildan Bozok | Investigation of the effects of in vitro fertilization and early embryogenesis on gap junction and adhesion proteins in an experimental Rattus albinus diabetes model | TÜBİTAK SBAG Project 109S457 | 2012 |
| Cumhur Gündüz, Çığır Biray Avcı, Cenk Can, Yavuz Dodurga, Hüsniye Sağlam, Burak Turna, Oktay Nazlı | Investigation of the synergistic effects of paclitaxel, plant-derived active compounds and endemic plant extracts on cell cycle and apoptotic signaling pathways in prostate cancer cell lines | TÜBİTAK SBAG Project 110S093 | 2012 |
| Yeniel, Ahmet Özgür; Ergenoğlu, Ahmet Mete; Zekioğlu, Osman; Selvi, Nur; Kaymaz, Burçin | Expression of cellular prion protein (PRPC) and COMMD-1 in normal preeclamptic cases with or without intrauterine growth restriction | TÜBİTAK SBAG Project 111S272 | 2012 |
| Ahmet Özbilgin, Cumhur Gündüz | Re-emergence and spread of Leishmania donovani sensu lato in Europe: molecular typing, population genetic analysis and risk management | TÜBİTAK SBAG Project 109S448 | 2013 |
| Tosun, Metiner; Kırmızıbayrak Ballar, Petek; Eraç, Yasemin; Kosova, Buket; Karakaya Selli, Çiğdem | Functional genomic analysis of the miRNA expression pattern associated with post-transcriptional control of TRPC ion channel genes in human primary aortic smooth muscle cells | TÜBİTAK SBAG Project 110S096 | 2013 |
| Yusuf Özbel, Seray Töz, Doç. Hüsniye Kayalar, İ. Cüneyt Balcıoğlu, Doç. İpek Östan, Doç. Fadile Zeyrek, Yrd. Doç. Cenk Durmuşkahya, Hatice Ertabaklar, Doç. Özgür Kurt, Cumhur Gündüz | In vitro and in vivo investigation of the anti-leishmanial effects of native plant species in Turkey | TÜBİTAK SBAG Project 110S289 | 2013 |
| Alkan, Mehmet Ziya; Alpman, Asude; Avcı, Çığır Biray; Töz, Seray; Özbel, Yusuf; Sözmen, Eser; Gündüz, Cumhur | Genome analysis of Leishmania tropica, the causative agent of cutaneous leishmaniasis in Turkey | TÜBİTAK SBAG Project 110S406 | 2013 |
| Nır Selvi Günel | Investigation of placental expression of cellular prion protein (PrPc) and the copper metabolism-related gene cluster COMMD1 in preeclamptic, intrauterine growth-restricted and healthy pregnant placentas | TÜBİTAK SBAG Project 111S272 | 2013 |
| Yavuz Anacak, Nezahat Olacak, Sunde Yılmaz Süslüer, Emine Serra Kamer, Cumhur Gündüz, Murat Olukman | Evaluation of the effects of intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques on cell-line survival responses using a novel radiobiological model | TÜBİTAK SBAG Project 113S367 | 2013 |
| Kasım Ocakoğlu, Fatma Yurt Lambchti Cumhur Gündüz | Synthesis of symmetric/asymmetric macrocyclic structures for tumor imaging and photodynamic therapy and comparison of their biological potentials | TÜBİTAK KBAG Proje 112T565 | 2014 |
| Ahmet Özbilgin, Cumhur Gündüz | Investigation of differences in Leishmania strains isolated from cutaneous leishmaniasis patients in Turkey using genotypic and proteomic methods and determination of their clinical reflections in a mouse model | TÜBİTAK SBAG Project 111S179 | 2014 |
| Yavuz Dodurga, Çığır Biray Avcı | Investigation of the possible mechanism of action of the sulfite molecule in human neuroblastoma cells (SH-SY5Y) through the novel oncogene URG4/URGCP | TÜBİTAK SBAG Project 113S167 | 2014 |
| Ferzan Lermioğlu Erciyas, Çığır Biray Avcı, Cumhur Gündüz | In vitro investigation of the effects of Cinnamomum cassia and C. zeylanicum bark extracts on endogenous and H2O2-induced oxidative DNA damage and repair in diabetes | TÜBİTAK SBAG Project 112S120 | 2015 |
| Yilmaz Süslüer Sunde, Özyazici Mine, Gündüz Cumhur, Kivçak Bijen, Fafal Tuğçe | Biosynthesis and characterization of Ag and Fe nanoparticles using Asphodelus aestivus extract and investigation of the antioxidant and antitumoral activities of the obtained nanoparticles | TÜBİTAK SBAG Project 114S730 | 2016 |
| Nır Selvi Günel | Preparation of LHRH receptor-targeted PEG-PLA-PGA triblock cisplatin-containing polymeric micelles for ovarian cancer and investigation of their oral use potential through in vitro, ex vivo and in vivo studies | TÜBİTAK SBAG Project 214S292 | 2016 |
| Biray Avcı Çiğir, Gündüz Cumhur, Ercan Gülinnaz, Vatansever Hafize Seda | Investigation of the anticancer activity of natural killer cells differentiated from adipose tissue-derived mesenchymal stem cells after co-culture with pancreatic cancer cells | TÜBİTAK SBAG Project 214S650 | 2016 |
| Metiner Tosun, Buket Kosova | Functional genomic analysis of store-operated calcium entry in the phenotypic differentiation of Huh-7 human hepatocellular carcinoma cell lines | TÜBİTAK SBAG Project 113S399 | 2017 |
| Akif Hakan Kurt, Vildan Bozok Çetintaş | Investigation of the proliferative and apoptotic effects of G protein-coupled estrogen receptor 1 (GPER1) in gastrointestinal adenocarcinoma cells | TÜBİTAK SBAG Project 113S912 | 2017 |
| İnce Ocakoğlu Mine, Gündüz Cumhur, Yurt Onaran Fatma, Ocakoğlu Kasim, Biray Avcı Çiğir | Synthesis and characterization of nanocarriers containing phthalocyanine derivatives and evaluation of their in vitro photodynamic therapy and tumor imaging activity | TÜBİTAK SBAG Project 114Z430 | 2017 |
| Vildan Bozok Çetintaş | Development of cell-derived exosome formulations carrying shRNA for anticancer applications | TÜBİTAK SBAG Project 115S829 | 2017 |
| Serin Sengel Süheyla, Köse Şükran, Biray Avcı Çiğir, Yilmaz Süslüer Sunde, Gündüz Cumhur | Investigation of long non-coding RNA expression in patients with hepatitis B | TÜBİTAK SBAG Project 214S225 | 2017 |
| Gülperi Öktem, Cumhur Gündüz, Fatih Oltulu | Investigation of cancer stem cell differentiation mediated by miRNA effects during embryonic reprogramming | TÜBİTAK KBAG Proje 115Z404 | 2018 |
| Ahmet Özbilgin, Cumhur GÜNDÜZ, Fadile Yildiz Zeyrek, Seray Töz, Gülnaz ÇULHA, Ühtü Tanıl KOCAGÖZ, Hatice ERTABAKLAR | Determination of the molecular mechanism of gene expression regulation responsible for the development of antimony resistance in Leishmania tropica | TÜBİTAK SBAG Project 214S239 | 2018 |
| Gülperi Öktem, Cumhur Gündüz, Fatih Oltulu | Investigation of cancer stem cell differentiation mediated by miRNA effects during embryonic reprogramming | TÜBİTAK SBAG Project 115S404 | 2018 |
| Kaymaz B., Avcı Ç.B. | Investigation of the effects of the IDH inhibitor AG-120, the TERT inhibitor BIBR1532 and their combination on glioma cells and cancer metabolism | Diğer Resmi Kurumlarca Desteklenen Proje | 2019 |
| Kantarcı A.G., Kotmakçı M., Çetıntaş V.B. | Development and in vitro evaluation of monoclonal antibody-coated miRNA/pDNA carrier solid lipid nanoparticles actively targetable to EGFR receptors of cancer cells | TÜBİTAK SBAG Project 115S566 | 2018 |
| Özbılgın A., Aydın E., Zeyrek F.Y., Kıtapçıoğlu G., Çulha G., Ertabaklar H., Çetın H., Balcıoğlu İ.C., Harman M., Ölgen M.K., Kasap Ö.E., Alten S.B., Demır S., Töz S., Uzun S., Arserım S.K., Gündüz, C, Özbel Y. | A parasitological, molecular and geographical epidemiological approach to the control of cutaneous leishmaniasis in Turkey | TÜBİTAK SBAG Project 114S999 | 2019 |
| Akbaba H., Kotmakçı M., Başpınar Y. Çetintaş, Vb | Development of ultrasound-sensitive nanobubble formulations carrying paclitaxel, a survivin inhibitor and siRNA against lung cancer | TÜBİTAK SBAG Project 116S213 | 2019 |
| Sözmen E.Y., Yıldırım H.K., Günel N.S | Reduction of allergenic molecule content in propolis through biotechnological transformation and evaluation of its effects on antioxidant/anti-inflammatory activity and apoptosis induction | TÜBİTAK KBAG Proje 116Z223 | 2019 |
| Özbılgın A., Gündüz C. | Product development studies for a parasite bank: design of diagnostic, educational and research kits for leishmaniasis | TÜBİTAK SBAG Project 217S550 | 2020 |
| Kınal A., Danyelı A.E., Demiroz G.A., Karasulu H.Y., Boyacıoğlu H., Yavaşoğlu N.Ü.K., Okur N.Ü., Günel N.S., Erbayraktar R.S., Şanlıer Ş., Erbayraktar Z. | A novel nanotechnological approach using solid lipid carriers for the treatment of glioblastoma | TÜBİTAK SBAG Project | 2020 |
| Bilge Melek Duygu, Yılmaz Süslüer Sunde, Bilge Metin, Anacak Yavuz, Gündüz Cumhur, Kamer Emine Serra, Parlak Cemal, Yalman Deniz | Determination of the anticancer properties of combined alternating electric field therapy (Tumor Treating Fields, TTF) and external radiotherapy in glioblastoma, brain cancer stem cell, brain stem cell and brain endothelial cell lines | TÜBİTAK SBAG Project 117S070 | 2020 |
| Nur Selvi Günel | The relationship between gastroesophageal reflux and diabetes mellitus: investigation of diabetes-induced changes in human esophageal epithelial integrity and tissue permeability using an in vitro mini-Ussing chamber system and identification of molecular markers involved in pathophysiological processes | TÜBİTAK SBAG Project 117S769 | 2020 |
| Vildan Bozok Çetintaş | Molecular investigation of the interconnections among Sonic Hedgehog signaling and related autophagy, apoptosis, cell cycle, cytoskeleton and hypoxia mechanisms following cyclopamine inhibition in co-cultures of glioblastoma multiforme, glioblastoma multiforme cancer stem cells and astrocytes | TÜBİTAK SBAG Project 117S578 | 2020 |
| Özlem Göksel, Cumhur Gündüz | Determination of molecular asthma endotypes through exhaled volatile organic compounds and peripheral blood microRNA biomarkers (VOC/miRNA-Endotype) | TÜBİTAK SBAG Project 116S196 | 2020 |
| Göker B., Gündüz C., Avcı Ç.B., Ay N.P.Ö. | Molecular investigation of the effects of Yes-associated protein 1 (YAP1) inhibition on stemness, adhesion, EMT, invasion and migration in brain cancer and brain cancer stem cells | Project Supported by Other Private Institutions | 2021 |
| Kaymaz B., Ulutaş B., Uyanıkgil E.Ö.Ç., Karasulu E., Tutar G., Türkyılmaz G.Y., Demiroz G.A., Güler G., Balyapan H., Boyacıoğlu H., Karaarslan I., Günel N.S., Şanlıer Ş., Arslan Y.E., Uyanıkgil Y. | Investigation of the efficacy of a targeted nanoparticle system containing dual drugs for topical chemotherapy in melanoma treatment | TÜBİTAK SBAG Project 219S788 | 2022 |
| Özbılgın A., Vardarlı A.T., Gündüz C. | Identification of putative genes and proteins responsible for viscerotropism of Leishmania tropica in humans | TÜBİTAK SBAG Project 119S469 | 2022 |
| Yaman B., Kosova B., Özgıray E., Eroğlu F.Z., Kotmakçı M., Akalın T., Çetintaş V.B. | Development of lipid nanoparticles carrying STING agonists and investigation of their effects on antitumor treatment response in a mouse model of glioblastoma | TÜSEB Proje 4469 | 2023 |
| Kosova B., Aktan Ç., Jafarı D.D.A., Eroğlu F.Z., Çetintaş V.B. | Determination of the dependence of chemotherapy-sensitive and resistant non-small cell lung cancer cells on nucleocytoplasmic transport components using a CRISPR/Cas9-based screening system | TÜBİTAK SBAG Project 119Z280 | 2023 |
| Demiroz G.A., Günel N.S., Şanlıer Ş. | Dual therapy in ovarian cancer treatment: preparation of a polymer-drug nanoconjugate targeting LPAR inhibition and its in vitro, in vivo and ex vivo investigation | TÜBİTAK SBAG Project 121S625 | 2024 |
| Vardarlı A.T. | Investigation of the potential of podocyturia as an atherosclerosis marker in diabetic patients and elucidation of its relationship with signaling pathways | TÜBİTAK SBAG Project 118S293 | 2024 |
| Kosova B., Kara H.G., Şentürk Ş., Çetintaş V.B. | Determination of the effects of Vps28 gene knockout on drug response and Golgi stress in chemotherapy-resistant solid tumors | TÜBİTAK SBAG Project 123Z193 | 2024 |
| Tomruk C., Gündüz C., Terek D., Erol E., Özkan E., Soylu F.E., Özdemir H.İ., Oran İ., Yalaz M., Bilge M.D., Bilge M., Günel N.S., Şanlıer Ş. | Determination of increased surfactant production by infrared phototherapy in lung alveolar cell lines and premature rat lungs | TÜBİTAK SBAG Project 221S431 | 2024 |
| Kaymaz B., Aslan R., Akgür S.A. | Investigation of synthetic cannabinoid-mediated therapeutic efficacy in chronic myeloid leukemia cell lines resistant to tyrosine kinase inhibitors | TÜBİTAK SBAG Project 123Z680 | 2024 |
| Kaymaz B., Yığıt E.Ö., Kızılkaya İ.T., Demır S., Öztürk Ş.B., Topçu Z. | Bioactivity-guided biomolecule isolation from the brown alga Cystoseira crinita and investigation of inhibition activity mechanisms on DNA topoisomerase enzymes using RNA-seq | TÜBİTAK SBAG Project 121Z249 | 2024 |
| Aşık A., Kosova B., Bara B., Ülker C., Gürel Ç., Akkafa F., Dilmeç F., Kara H.G., Akbaş H., Özateş N.P., Bozok V. | Investigation of the antitumoral effects of amcasertib, a cancer stemness kinase inhibitor, in a xenograft ovarian cancer model | TÜSEB Proje 18036 | 2025 |
| Bay B.Ö., Avcı Ç.B., Ünsalan Ç.A., Binboğa E., Aktuğ H., Ünsalan O. | Molecular, morphological and spectroscopic analysis of the possible effects of JNK inhibition in a breast cancer cell line | TÜBİTAK SBAG Project 224S529 | 2025 |
| Erışık D., Şen E., Göker E.N.T., Tavmergen E., Acet F., Çetintaş V.B., Uyanıkgil Y. | Efficacy of adipose tissue-derived mesenchymal stem cell applications in thin endometrium regeneration in a rat model | Diğer Resmi Kurumlarca Desteklenen Proje TS-TUT-2023-28431 | 2025 |
| Ali Saffet Gönül, Buket Kosova | Comparison of default mode, short-term memory encoding and recall-related neural components in individuals diagnosed with mild cognitive impairment with early Alzheimer's disease patients, their healthy siblings and controls | TÜBİTAK SBAG Project 214S029 | Ongoing |
| Tuncay Göksel, Özlem Göksel, Cumhur Gündüz | Use of liquid and volatile biopsy in individualized molecular diagnosis and follow-up of patients with lung cancer | TÜBİTAK SBAG Project 216S591 | Ongoing |
| Kaymaz B. | Artificial intelligence-based investigation of RNA sequencing data for a STAT5 inhibition-mediated therapeutic strategy in ex vivo culture of progenitor stem cells from CML patients resistant to the tyrosine kinase inhibitor imatinib | TÜSEB 32519 | Ongoing |
| Kosova B., Gündüz C., Aktan Ç., Gürel Ç., Akkafa F., Dilmeç F., Kara H.G., Akbaş H., Özateş N.P., Yılmaz Ş.G., Şentürk Ş., Çetintaş V.B. | Therapeutic targeting of glutathione metabolism genes associated with restoration of paclitaxel sensitivity in breast cancer using different gene-editing technologies | TÜBİTAK SBAG Project 123Z612 | Ongoing |
| Yaman B., Kosova B., İstanbullu H., Çetintaş V.B., Düzgün Z. | Characterization of small-molecule inhibitors that block STING-mediated TBK1 activation | TÜBİTAK SBAG Project 123Z300 | Ongoing |
| Yavaşoğlu A., Buhur A., Gürel Ç., Avcı Ç.B., Şancı E., Açıkgöz E., Oltulu F., Kuşçu G.C., Yavaşoğlu N.Ü.K., Günel N.S. | Effects of PCAF gene knockout on neurodegeneration-related processes in an experimental Parkinson's disease model | TÜSEB 22703 | Ongoing |
| Vardarlı A.T., Caner A., Gündüz C., Pelit F., Pelit L., Doğanay Ö., Göksel Ö., Çeliktaş Ö.Y., Göksel T. | Development of innovative biomedical devices in respiratory diseases through a translational medicine approach | CB Strateji ve Bütçe Başkanlığı (Kalkınma Bakanlığı) Projesi 21531 | Ongoing |
| Kaymaz B. | Combined use of an epigenetic agent and adjuvant immunotherapy in conventional treatment of triple-negative breast cancer: development and evaluation of the efficacy of a next-generation drug strategy | TÜSEB 24430 | Ongoing |
| Çetintaş V.B. | Investigation of the roles of HIP1R, RHEBL1 and RNF149 genes in cGAS/STING activation | TÜBİTAK SBAG Project 123Z456 | Ongoing |
| Kaymaz B. | Determination of the bioactivity and antimultiple myeloma effects of various cyanobacteria | TÜBİTAK Uluslararası İkili İşbirliği Projesi 2530 | Ongoing |
| Kaymaz B. | Determination of the expression profile of circRNAs specific to oncogenic signaling pathways in the investigation of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia | TÜBİTAK Project 2209 - A | Ongoing |
| Kaymaz B. | Investigation of synthetic cannabinoid-mediated therapeutic efficacy in chronic myeloid leukemia cell lines resistant to tyrosine kinase inhibitors | TÜBİTAK SBAG Project 123Z680 | Ongoing |
| Kaymaz B. | Investigation of the effects of novel synthetic cannabinoids delivered by a zinc-ZIF8-based metal-organic framework carrier system on overcoming imatinib resistance in leukemia through an integrated proteomic and RNA sequencing bioinformatics approach | TÜBİTAK SBAG Project 124Z784 | Ongoing |
| Vardarlı A.T., Gündüz C., Karakuş H.S., Pelit L., Özgür S., Göksel T. | Detection of specific circRNAs by ddPCR in exhaled breath condensate samples from patients diagnosed with non-small cell lung cancer | TÜSEB 33645 | Ongoing |
| veral A., Vardarlı A.T., Aşık A., Gündüz C., Karakuş H.S., Ceylan K.C., Turhan K., Pelit L., Usluer O., Savaş R., Özgür S., Akçam T.İ., Göksel T. | Evaluation of genomic profiles in exhaled breath condensate samples from patients diagnosed with early-stage lung cancer as early diagnostic biomarkers | TÜBİTAK SBAG Project 123S548 | Ongoing |
| Gündüz C. | Establishment of functional membrane-surface expression of CD4 and the chemokine receptors CCR5 and CXCR4 | TÜSEB 33102 | Ongoing |
| Avcı Ç.B. | The interaction between exercise and brain lipid metabolism in protection against Alzheimer's disease | TÜBİTAK International Multi-partner Cooperation Project 123N868 | Ongoing |
| Vardarlı A.T., Yalman D., Soya E., Köylü M., Doğanay Ö., Savaş R., Toprak T., Göksel T. | Development of a novel radiogenomic technique enabling early diagnosis of radiation pneumonitis in non-small cell lung cancer | TÜBİTAK SBAG Project 123S719 | Ongoing |
