This page presents the theses prepared within the department in a structured archive format, including author, thesis title, supervisor and year information.
PhD Theses
Author
Thesis Title
Supervisor
Year
Mehmet Ali Kuru
Experimental investigation of the effects of electrically heated tablet preparations used against mosquitoes on respiratory system cells of inbred mice
Prof. Dr. Nejat Topçuoğlu
1991
Berna Yılmaz
Demonstration of intermediate filaments in central nervous system tumor cells by the immunofluorescence method
Prof. Dr. M. Ali Özcel
1991
Zuhal Balım
Comparison of DNA values in normal proximal tubule epithelium and renal adenocarcinoma cells by microspectrophotometric measurements
Prof. Dr. Nejat Topçuoğlu
1991
Gül Sapmaz
Karyotype and BrdU studies in mothers with toxoplasmosis
Prof. Dr. Cihangir Özkınay
1992
Nuray Altıntaş
Investigation of protozoa living in the digestive system of termites in the Aegean Region and evaluation of their similarities with human digestive system protozoa
Prof. Dr. M. Ali Özcel
1994
Cumhur Gündüz
Comparative investigation of chorionic villus karyotype and fetal karyotype in maternal blood in medically indicated abortions performed at the request of the family
Prof. Dr. Cihangir Özkınay
1994
Berrin Tuğrul
Investigation of Factor V Leiden and prothrombin 20210A mutations in patients with deep vein thrombosis and Factor V Leiden analysis using electrochemical DNA biosensors
Prof. Dr. Nejat Topçuoğlu
2003
Nur Selvi
Investigation of t(8;14) and t(14;18) chromosomal rearrangements by polymerase chain reaction in paraffin sections from patients diagnosed with Burkitt lymphoma and follicular lymphoma
Prof. Dr. Nejat Topçuoğlu
2009
Çığır Biray Avcı
The significance of tumor suppressor genes and oncogenes in the diagnosis and prognosis of anaplastic brain tumors
Doç. Dr. Cumhur Gündüz
2009
Yavuz Dodurga
Correlation of upregulated gene 4 (URG4), as a novel approach in leukemogenesis, with gene expression in signal transduction pathways
Prof. Dr. Nejat Topçuoğlu
2010
Burçin Kaymaz
Suppression of STAT3, STAT5A and STAT5B expression by modified siRNAs in the K562 leukemia cell line and induction of apoptosis
Yrd. Doç. Dr. Buket Kosova
2010
Vildan Bozok Çetintaş
Effects of 14-3-3 sigma expression and methylation levels on the development of chemotherapy resistance in non-small cell lung cancer cell lines
Prof. Dr. Nejat Topçuoğlu
2011
Aslı Tetik Vardarlı
Determination of genomic profiles of cardiovascular diseases, primary dyslipidemia and diabetic dyslipidemia
Doç. Dr. Zuhal Eroğlu
2011
Zeynep Özlem Doğan Şığva
Investigation of the synergistic effects of paclitaxel, plant-derived active compounds and endemic plant extracts on cell cycle and apoptosis signal transduction pathways in prostate cancer cell lines
Prof. Dr. Cumhur Gündüz
2012
Sunde Yılmaz Süslüer
Determination of miRNA expression changes in diffuse and high-grade glial tumors
Prof. Dr. Cumhur Gündüz
2012
Çağdaş Aktan
Identification of androgen receptor-targeting miRNAs in androgen-sensitive and castration-resistant prostate cancer cell lines and investigation of resistance mechanisms involving other target genes
Doç. Dr. Buket Kosova
2013
Ayşegül Dalmızrak
Determination of the effects of the chemotherapeutic agent rituximab on JAK-STAT and NF-kB signaling pathways in acute lymphoblastic leukemia and chronic lymphocytic leukemia cell lines
Doç. Dr. Buket Kosova
2014
Duygu Aygüneş
Effects of trastuzumab, docetaxel and fucoidan, used as single agents and in combination, on apoptosis and cytotoxicity in breast cancer cell lines
Doç. Dr. Buket Kosova
2014
Tuğçe Balcı
Investigation of the functions of long non-coding RNAs in brain tumors
Prof. Dr. Cumhur Gündüz
2015
Ali Şahin Küçükaslan
Investigation of the relationship between SIRT1 gene expression and SIRT1-targeting miRNAs in the H9c2 cell line exposed to high glucose
Doç. Dr. Zuhal Eroğlu
2016
Çağla Kayabaşı
Effects of the therapeutic agents ponatinib and VS-5584 on chronic myeloid leukemia leukemogenesis
Prof. Dr. Cumhur Gündüz
2018
Besra Özmen Yelken
In vitro evaluation of the anticancer activity of a resveratrol analogue in prostate cancer cells
Prof. Dr. Cumhur Gündüz
2018
Zeynep Mutlu
Molecular investigation of long non-coding RNA expression in tyrosine kinase inhibitor-sensitive and -resistant chronic myeloid leukemia patients
Doç. Dr. Çığır Biray Avcı Doç. Dr. Archa Fox
2018
Nevin Oruç
The significance of lncRNAs in the diagnosis and prognosis of pancreatic cancer
Doç. Dr. Zuhal Eroğlu
2019
Meltem Seziş Demirci
Investigation of differential expression profiles of the transient receptor potential ion channel (TRPC) gene family in patients undergoing kidney biopsy with clinical suspicion of glomerulonephritis
Doç. Dr. Buket Kosova
2019
İpek Kaplan Bulut
Evaluation of suPAR and SIRT1 as cardiovascular markers in pediatric patients with chronic kidney disease
Doç. Dr. Buket Kosova
2019
Metin Çalışkan
Investigation of oncogenic alterations in peripheral blood cell-free DNA (cfDNA) samples after first-line therapy in patients with lung adenocarcinoma
Doç. Dr. Nur Selvi Günel
2019
Ahmet Çağ Çal
Effect of zoledronic acid treatment on cell adhesion molecules in prostate cancer stem cells
Prof. Dr. Cumhur Gündüz
2019
Sezgi Kıpçak
Determination of epithelial molecules involved in the etiopathogenesis of achalasia and investigation of epithelial permeability
Doç. Dr. Nur Selvi Günel
2021
Bakiye Göker
Determination of a genomic profile that may constitute a therapeutic target in paranasal sinus carcinogenesis
Doç. Dr. Çığır Biray Avcı
2021
Hale Güler Kara
Identification of genetic factors involved in the development of cisplatin resistance in non-small cell lung cancer using a CRISPR-Cas9-based whole-genome screening system
Doç. Dr. Buket Kosova
2021
Neslihan Pınar Özateş
Investigation of the effects of inhibition of the Hippo signaling pathway effector molecule YAP1 on in vitro brain cancer and brain cancer stem cells
Doç. Dr. Çığır Biray Avcı
2021
Aycan Aşık
Investigation of genetic factors in the molecular pathogenesis of hereditary angioedema without SERPING1 mutation
Prof. Dr. Cumhur Gündüz
2022
Aygül Çeltik
Evaluation of the association of two major diabetes complications with Nrf2 gene polymorphisms
Doç. Dr. Fatma Zuhal Eroğlu
2022
Cansu Çalışkan Kurt
Molecular investigation of the effects of the combination of maslinic acid and oleanolic acid on the Wnt signaling pathway in breast cancer
Doç. Dr. Çığır Biray Avcı
2022
Buket Özel
Development of a polymer-drug nanoconjugate for ovarian cancer and investigation of its cancer therapeutic potential
Doç. Dr. Nur Selvi Günel
2022
Ahmet Keskinoğlu
Effect of endoplasmic reticulum stress on graft functions in pediatric kidney transplant recipients with hypertension
Doç. Dr. Fatma Zuhal Eroğlu Prof. Dr. Muhsin Özgür Çoğulu
2023
Latife Merve Oktay Çelebi
Investigation of the bioactivity of cnicin in combination with conventional chemotherapeutic agents and its effects on molecules involved in cancer-related signaling pathways
Doç. Dr. Nur Selvi Günel
2023
Fatma Söğütlü
Epigenetic evaluation of the anticancer role of thyme oil in gastric cancer
Doç. Dr. Çığır Biray Avcı
2023
Mesude Angın
Somatic mutation analysis of BRAF, NRAS, TERT and TP53 genes in anaplastic thyroid cancer
Prof. Dr. Emin Karaca
2024
Fazilet Esra Düzdağ
Investigation of the efficacy of combined use of an epigenetic agent and adjuvant immunotherapy in the conventional treatment of triple-negative breast cancer
Doç. Dr. Burçin Kaymaz
2024
Roya Gasımlı
Investigation of the effects of silencing mitochondrial mutant gene expression on carcinogenesis in a lung cancer cell model
Prof. Dr. Cumhur Gündüz
2024
Eda Doğan
Effects of endoplasmic reticulum-Golgi vesicular trafficking on STING activation
Doç. Dr. Vildan Bozok Çetintaş
2024
Özlem Göksel
Investigation of the roles of circular RNAs in different asthma severity grades
Prof. Dr. Cumhur Gündüz
2024
İbrahim Halil Çitçi
Effects of TCF7L2 on nicotine dependence and glucose metabolism in nicotine-dependent rat strains
Prof. Dr. Buket Kosova
2024
Semahat Çelikten
Effect of thapsigargin on ER stress and cisplatin resistance in cisplatin-resistant Calu-1 and H030 non-small cell lung cancer cell lines
Prof. Dr. Vildan Bozok
2025
Deniz Bolat
Investigation of urinary circular RNAs as potential biomarkers in the diagnosis of bladder cancer
Doç. Dr. Burçin Kaymaz
2025
Selahattin Alperen Uysal
Identification of novel drug targets for the treatment of Alzheimer disease through gene expression analysis data
Doç. Dr. Burçin Kaymaz
2025
Umut Öztürk
Investigation of the relationship between specific miRNAs and E-cadherin and vimentin expression in exhaled breath condensate samples from patients with non-small cell lung cancer
Doç. Dr. Aslı Tetik Vardarlı
2025
İsmail Mert Alkaç
Enhancement of therapeutic efficacy by miRNA silencing of genes that confer resistance to CDK inhibitors in breast cancer
Prof. Dr. Çığır Biray Avcı
2025
Sanem Keskin Yılmaz
Optical genome mapping as a novel method in the diagnostic algorithm of developmental and epileptic encephalopathies of undetermined genetic etiology
Doç. Dr. Nur Selvi Günel
2025
Leıla Sabour Takanlou
Investigation of the potential of the EZH2 inhibitor tazemetostat as an alternative therapeutic target in gastric cancer
Prof. Dr. Çığır Biray Avcı
2025
Büşra BARA
Evaluation of the efficacy of mesenchymal stem cell-derived exosomes administered intravitreally and sub-Tenon in an experimental diabetic retinopathy model
Prof. Dr. Vildan Bozok
2026
Doç. Dr. Miray KARAKOYUN
Identification of novel gene variants associated with monogenic inflammatory bowel disease by whole-exome sequencing analysis
Prof. Dr. Vildan Bozok
2026
Doç. Dr. Nalan GÜLŞEN ÜNAL
Poly(ADP-ribose) polymerase-1 gene expression, chromatin remodeling complex and Toll-like receptor methylation in inflammatory bowel disease
Prof. Dr. Çığır Biray Avcı
2026
İlayda ALÇITEPE
Investigation of the effects of pimozide treatment, a STAT5 inhibitor, on chemosensitivity and leukemogenesis in tyrosine kinase inhibitor-responsive and -resistant CML stem cells
Prof. Dr. Burçin Kaymaz
2026
Maryam SABOUR TAKANLOU
Investigation of the molecular effect of inhibition of the N6-methyladenosine reader YTHDF2 on glioblastoma cells
Prof. Dr. Çığır Biray Avcı
2026
